AIPL1

Across TCGA patient cohorts, AIPL1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIPL1-associated genes across cancer lineages are Notch1, PRAS40_pT246, and C-Raf. Each is linked with AIPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIPL1-to-partner and partner-to-AIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by AIPL1-low versus AIPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIPL1→partner) and Y-score (partner→AIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.176	+3.335	.003	.005	3	2
UCEC	PRAS40_pT246 →	+0.172	+1.713	.018	.027	3	2
UCEC	C-Raf →	+0.242	+3.321	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.090	-1.687	.035	.044	3	1
UCEC	EGFR_pY1068 →	-0.268	-1.700	.011	.044	3	1
UCEC	eIF4E →	+0.200	+3.459	.025	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by AIPL1 expression — UCEC

Explore this box plot interactively →