AIPL1

Across TCGA cell cohorts, AIPL1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIPL1-associated genes across cancer lineages are C16orf92, PRR30, and CSN2. Each is linked with AIPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIPL1-to-partner and partner-to-AIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by AIPL1-low versus AIPL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIPL1→partner) and Y-score (partner→AIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf92 →	+0.122	+4.037	.005	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.010	+4.269	.002	.002	3	1
SKIN	CSN2 →	+0.078	+4.415	<.001	.007	3	1
SKIN	OR5A1 →	+0.015	+5.022	<.001	.002	3	1
SKIN	ZNF99 →	+0.049	+4.273	<.001	.006	3	1
LARGE_INTESTINE	RPA1 →	+0.911	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

C16orf92 by AIPL1 expression — BLOOD_Leukemia

Explore this box plot interactively →