AIP

Across TCGA cell cohorts, AIP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AIP-associated genes across cancer lineages are ITGAD, SLC15A5, and TACR3. Each is linked with AIP in more than 1 cancer types. Because this analysis shows association rather than direction, both AIP-to-partner and partner-to-AIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by AIP-low versus AIP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIP→partner) and Y-score (partner→AIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Leukemia	TACR3 →	+0.040	+5.475	<.001	<.001	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CGB8 →	+0.048	+3.551	.001	.009	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ITGAD by AIP expression — LARGE_INTESTINE

Explore this box plot interactively →