Across TCGA pan-cancer cohorts, AIMP1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of AIMP1P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where AIMP1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AIMP1P1 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
KICH and ESCA are the cancer types where AIMP1P1 tumor–normal differential expression is most reproducible.