AIM2

Across TCGA patient cohorts, AIM2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIM2-associated genes across cancer lineages are FASN, p53, and Myosin-IIa. Each is linked with AIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIM2-to-partner and partner-to-AIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by AIM2-low versus AIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIM2→partner) and Y-score (partner→AIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.483	+1.807	.002	.027	3	2
SKCM	p53 →	-0.254	-2.982	.018	.036	3	1
UCEC	Myosin-IIa →	+0.181	+2.007	.030	.018	3	1
UCEC	Notch1 →	+0.218	+2.594	<.001	.006	3	1
UCEC	p62 Lck ligand →	+0.283	+2.179	.035	.034	3	1
UCEC	PDCD4 →	-0.576	-1.807	.003	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FASN by AIM2 expression — UCEC

Explore this box plot interactively →