AIM2

Across TCGA cell cohorts, AIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,320 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AIM2-associated GO terms across cancer lineages are Defense response to virus, Regulation of viral process, and Innate immune response-activating signaling pathway. Each is linked with AIM2 in more than 9 cancer types. Because this analysis shows association rather than direction, both AIM2-to-partner and partner-to-AIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to virus grouped by AIM2-low versus AIM2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AIM2→partner) and Y-score (partner→AIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.125	+2.671	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.115	+2.125	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Innate immune response-activating signaling pathway →	+0.083	+2.457	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Activation of innate immune response →	+0.090	+2.329	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Pattern recognition receptor signaling pathway →	+0.085	+2.753	<.001	<.001	3	8
SOFT_TISSUE	Regulation of T cell anergy →	+0.831	+1.003	.002	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

Defense response to virus by AIM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →