AIM2

Across TCGA cell cohorts, AIM2 mutation is significantly associated with the mutation status of many other genes, with 4,166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIM2-associated genes across cancer lineages are ZFAT, DENND5B, and ABCC2. Each is linked with AIM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AIM2-to-partner and partner-to-AIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFAT grouped by AIM2-low versus AIM2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIM2→partner) and Y-score (partner→AIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZFAT →	+5.115	+5.115	.005	.005	1	4
PANCREAS	DENND5B →	+5.115	+5.115	.005	.005	1	3
LARGE_INTESTINE	ABCC2 →	+2.781	+4.504	<.001	<.001	1	3
LARGE_INTESTINE	HSF2 →	+4.459	+4.459	<.001	<.001	1	3
LARGE_INTESTINE	BTN3A1 →	+2.289	+3.182	.008	.008	1	3
LARGE_INTESTINE	PRSS22 →	+4.459	+4.459	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,166 associations by consensus.

ZFAT by AIM2 expression — PANCREAS

Explore this box plot interactively →