AIG1

Across TCGA pan-cancer cohorts, AIG1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of AIG1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where AIG1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types AIG1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

PDAC, HNSC, and LSCC are the cancer types where AIG1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AIG1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	+0.496	.003	6	view →
HNSC	All	II,III,IV	−0.247	.002	6	view →
LSCC	All	All	+0.361	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

AIG1–PDAC

Open the PDAC breakdown →