AIG1

Across TCGA patient cohorts, AIG1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIG1-associated genes across cancer lineages are eIF4E, INPP4B, and Notch1. Each is linked with AIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIG1-to-partner and partner-to-AIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AIG1-low versus AIG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIG1→partner) and Y-score (partner→AIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.253	+3.169	.029	.020	3	1
UCEC	INPP4B →	-0.424	-2.999	.016	.035	3	1
UCEC	Notch1 →	+0.251	+3.013	.001	.018	3	1
UCEC	p62 Lck ligand →	+0.554	+3.009	.001	.019	3	1
UCEC	STAT3_pY705 →	-0.516	-3.169	<.001	.020	3	1
UCEC	Tuberin →	+0.436	+3.169	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by AIG1 expression — UCEC

Explore this box plot interactively →