AIG1

Across TCGA cell cohorts, AIG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,676 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AIG1-associated GO terms across cancer lineages are Regulation of proteolysis, Regulation of muscle atrophy, and Response to topologically incorrect protein. Each is linked with AIG1 in more than 10 cancer types. Because this analysis shows association rather than direction, both AIG1-to-partner and partner-to-AIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by AIG1-low versus AIG1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AIG1→partner) and Y-score (partner→AIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of proteolysis →	+0.114	+2.775	<.001	<.001	3	11
BLOOD_Lymphoma	Regulation of muscle atrophy →	+0.471	+1.343	<.001	<.001	3	10
BONE	Response to topologically incorrect protein →	+0.087	+2.918	<.001	<.001	3	10
SKIN	Cellular response to nitrogen levels →	+0.152	+1.407	<.001	<.001	3	10
BONE	Long-chain fatty acid catabolic process →	+1.489	+3.645	<.001	<.001	3	10
LUNG_SCLC	Type II interferon-mediated signaling pathway →	+0.128	+1.139	.002	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,676 associations by consensus.

Regulation of proteolysis by AIG1 expression — BONE

Explore this box plot interactively →