AIG1

Across TCGA cell cohorts, AIG1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIG1-associated genes across cancer lineages are SLC32A1, MS4A10, and TBC1D21. Each is linked with AIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIG1-to-partner and partner-to-AIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by AIG1-low versus AIG1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIG1→partner) and Y-score (partner→AIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC32A1 →	+0.991	+4.017	<.001	.007	3	1
OESOPHAGUS	MS4A10 →	+0.007	+4.857	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10R2 →	+0.031	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.145	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SLC32A1 by AIG1 expression — OESOPHAGUS

Explore this box plot interactively →