Across TCGA patient cohorts, AIFM3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,273 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AIFM3-associated genes across cancer lineages are PRODH, SEPTIN3, and SUN2. Each is linked with AIFM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIFM3-to-partner and partner-to-AIFM3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM3→partner) and Y-score (partner→AIFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.838	+0.575	<.001	<.001	3	1
GBM	SEPTIN3 →	+1.027	+0.470	.002	.003	3	1
GBM	SUN2 →	+0.344	+0.411	.007	.006	3	1
GBM	RASL10A →	+0.664	+0.446	<.001	<.001	3	1
GBM	NEFH →	+1.292	+0.632	<.001	<.001	3	1
GBM	RASD2 →	+0.559	+0.603	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,273 associations by consensus.

Exploration

AIFM3 survival (RNA) · tumor vs normal (RNA) · all AIFM3 data types