Across TCGA patient cohorts, AIFM3 mutation is significantly associated with the RNA expression of many other genes, with 4,334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIFM3-associated genes across cancer lineages are GHITM, HNRNPMP2, and COX15. Each is linked with AIFM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AIFM3-to-partner and partner-to-AIFM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM3→partner) and Y-score (partner→AIFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHITM →	+0.581	+2.321	<.001	.001	3	4
CESC	HNRNPMP2 →	+0.059	+4.757	<.001	.004	3	3
COAD	COX15 →	+0.493	+3.472	<.001	.002	2	4
UCEC	EIF4E →	+0.417	+2.922	.002	<.001	3	3
UCEC	DONSON →	+0.452	+2.230	.003	.006	3	3
COAD	ADPGK →	+0.516	+3.486	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,334 associations by consensus.

Exploration

AIFM3 survival (RNA) · tumor vs normal (RNA) · all AIFM3 data types