Across TCGA patient cohorts, AIFM3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIFM3-associated genes across cancer lineages are eIF4E, HER3_pY1289, and 4E-BP1. Each is linked with AIFM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AIFM3-to-partner and partner-to-AIFM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM3→partner) and Y-score (partner→AIFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.266	+2.832	.006	.035	3	3
COAD	HER3_pY1289 →	+0.158	+2.832	.002	.035	3	2
COAD	4E-BP1 →	+0.400	+2.815	<.001	.036	3	2
UCEC	Notch1 →	+0.169	+3.469	.001	.002	3	2
UCEC	PCNA →	+0.207	+1.678	.012	.023	3	2
UCEC	STAT3_pY705 →	-0.316	-2.212	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

AIFM3 survival (RNA) · tumor vs normal (RNA) · all AIFM3 data types