AIFM2

Across TCGA patient cohorts, AIFM2 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,679 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AIFM2-associated proteins across cancer lineages are FERMT3, HSD17B11, and SAFB. Each is linked with AIFM2 in more than 6 cancer types. Because this analysis shows association rather than direction, both AIFM2-to-partner and partner-to-AIFM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AIFM2 versus FERMT3 in LSCC, with a Pearson correlation of 0.61.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM2→partner) and Y-score (partner→AIFM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FERMT3 →	+0.515	+0.332	<.001	<.001	3	7
CCRCC	HSD17B11 →	+0.497	+0.459	<.001	<.001	3	6
GBM	SAFB →	-0.266	-0.271	<.001	<.001	3	5
OV	HDGFL2 →	-0.374	-0.388	<.001	<.001	3	5
GBM	STAG2 →	-0.395	-0.379	.001	<.001	3	5
LSCC	WAS →	+0.477	+0.314	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,679 associations by consensus.

AIFM2 vs FERMT3 — LSCC

Explore this scatter interactively →