AIFM1

Across TCGA pan-cancer cohorts, AIFM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AIFM1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AIFM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AIFM1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where AIFM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.917	.010	78	view →
PDAC	DFS	Median	All	0.487	0.233	<.001	55	view →
LUAD	OS	Median	III,IV	0.808	0.298	.013	7	view →
UCEC	OS	Median	All	0.858	0.965	.035	4	view →
HNSC	DFS	Tertile	All	0.661	0.840	.041	3	view →
LSCC	DFS	Median	All	0.896	0.972	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AIFM1–COAD (DFS)

Open the COAD breakdown →