AIFM1

Across TCGA patient cohorts, AIFM1 mutation is significantly associated with the RNA expression of many other genes, with 4,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIFM1-associated genes across cancer lineages are RNU6-1270P, SAP18, and C18orf25. Each is linked with AIFM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AIFM1-to-partner and partner-to-AIFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1270P grouped by AIFM1-low versus AIFM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM1→partner) and Y-score (partner→AIFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1270P →	+0.158	+4.900	<.001	.002	3	3
UCEC	SAP18 →	+0.262	+3.721	.001	<.001	3	2
UCEC	C18orf25 →	+0.407	+1.868	<.001	<.001	3	2
UCEC	FARP1 →	+0.484	+2.110	<.001	<.001	3	2
UCEC	SLC30A7 →	+0.413	+3.010	<.001	<.001	3	2
UCEC	HSPA4L →	+0.887	+2.595	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,802 associations by consensus.

RNU6-1270P by AIFM1 expression — SKCM

Explore this box plot interactively →