AIFM1

Across TCGA patient cohorts, AIFM1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIFM1-associated genes across cancer lineages are ACC1, JNK_pT183_Y185, and Akt_pT308. Each is linked with AIFM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIFM1-to-partner and partner-to-AIFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by AIFM1-low versus AIFM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM1→partner) and Y-score (partner→AIFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.232	+2.013	.046	.016	3	2
UCEC	JNK_pT183_Y185 →	-0.132	-2.087	.014	.005	3	2
UCEC	Akt_pT308 →	+0.400	+1.289	.046	.023	3	2
UCEC	Rab25 →	-0.293	-2.459	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.166	-1.289	.038	.023	3	1
UCEC	eIF4E →	+0.151	+1.777	.025	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ACC1 by AIFM1 expression — UCEC

Explore this box plot interactively →