AIFM1

Across TCGA cell cohorts, AIFM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,671 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AIFM1-associated GO terms across cancer lineages are Quinone metabolic process, Quinone biosynthetic process, and Ubiquinone biosynthetic process. Each is linked with AIFM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both AIFM1-to-partner and partner-to-AIFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Quinone metabolic process grouped by AIFM1-low versus AIFM1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM1→partner) and Y-score (partner→AIFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Quinone metabolic process →	+0.085	+0.948	.002	.001	3	14
BREAST	Quinone biosynthetic process →	+0.089	+0.613	<.001	<.001	3	14
BREAST	Ubiquinone biosynthetic process →	+0.089	+0.613	<.001	<.001	3	14
PANCREAS	snRNA pseudouridine synthesis →	+0.075	+0.694	<.001	<.001	3	12
BREAST	Ubiquinone metabolic process →	+0.089	+0.858	<.001	<.001	3	12
BONE	Mitochondrial large ribosomal subunit assembly →	+0.132	+0.911	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,671 associations by consensus.

Quinone metabolic process by AIFM1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →