AIF1L

Across TCGA patient cohorts, AIF1L mutation is significantly associated with the RNA expression of many other genes, with 171 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIF1L-associated genes across cancer lineages are RNA5SP198, TRMU, and NOM1. Each is linked with AIF1L in more than 1 cancer types. Because this analysis shows association rather than direction, both AIF1L-to-partner and partner-to-AIF1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by AIF1L-low versus AIF1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIF1L→partner) and Y-score (partner→AIF1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP198 →	+0.559	+3.036	<.001	.009	3	2
UCEC	TRMU →	+0.491	+3.459	.002	.005	3	1
UCEC	NOM1 →	+0.471	+3.480	.005	.002	3	1
UCEC	MRRF →	+0.553	+3.459	<.001	.005	3	1
UCEC	RPL23AP90 →	+0.328	+2.641	.007	.005	3	1
UCEC	SNORD11B →	+0.621	+2.546	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

RNA5SP198 by AIF1L expression — UCEC

Explore this box plot interactively →