Across TCGA patient cohorts, AIDA mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIDA-associated genes across cancer lineages are eIF4G, JNK2, and p70-S6K_pT389. Each is linked with AIDA in more than 1 cancer types. Because this analysis shows association rather than direction, both AIDA-to-partner and partner-to-AIDA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIDA→partner) and Y-score (partner→AIDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.320	+3.000	.040	.036	3	1
UCEC	JNK2 →	+0.284	+3.009	.004	.019	3	1
UCEC	p70-S6K_pT389 →	-0.244	-3.459	.010	.005	3	1
UCEC	P-Cadherin →	-0.163	-3.159	.024	.019	3	1
UCEC	STAT3_pY705 →	-0.516	-3.169	<.001	.018	3	1
UCEC	C-Raf →	+0.203	+3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

AIDA survival (RNA) · tumor vs normal (RNA) · all AIDA data types