AICDA

Across TCGA patient cohorts, AICDA mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AICDA-associated genes across cancer lineages are Gab2, A-Raf_pS299, and Notch1. Each is linked with AICDA in more than 2 cancer types. Because this analysis shows association rather than direction, both AICDA-to-partner and partner-to-AICDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by AICDA-low versus AICDA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AICDA→partner) and Y-score (partner→AICDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.307	+2.321	.037	.006	3	3
UCEC	A-Raf_pS299 →	-0.133	-2.321	.006	.034	3	2
UCEC	Notch1 →	+0.207	+3.183	<.001	.009	3	2
UCEC	p27_pT198 →	+0.089	+2.999	.043	.035	3	2
UCEC	STAT5a →	+0.351	+3.321	.033	.010	2	3
UCEC	Syk →	+0.383	+1.820	.013	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Gab2 by AICDA expression — UCEC

Explore this box plot interactively →