AHSP

Across TCGA pan-cancer cohorts, AHSP RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated AHSP data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AHSP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AHSP expression acts as an unfavorable survival marker, although some lineages such as PCPG and KIRC show a favorable association.

COAD, ACC, and THCA are the cancer types where AHSP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.681	0.809	.005	25	view →
ACC	OS	Quartile	II,III,IV	0.269	0.814	<.001	22	view →
THCA	OS	Tertile	II,III,IV	0.955	1.000	.008	18	view →
PCPG	DFS	Quartile	All	1.000	0.639	.018	17	view →
READ	OS	Quartile	III,IV	0.416	0.812	.002	16	view →
KIRC	DFS	Median	All	0.902	0.851	.023	10	view →
STAD	OS	Median	IV	0.617	0.328	.017	9	view →
BLCA	OS	Median	IV	0.169	0.352	.019	7	view →
OV	DFS	Median	IV	0.398	0.236	.028	6	view →
LAML	DFS	Median	All	0.652	0.471	.022	6	view →
PAAD	OS	Median	III,IV	0.723	1.000	.045	3	view →
MESO	OS	Quartile	All	0.486	0.667	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

AHSP–COAD (DFS)

Open the COAD breakdown →