AHI1

Across TCGA patient cohorts, AHI1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHI1-associated genes across cancer lineages are ASNS, MSH2, and ATM. Each is linked with AHI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AHI1-to-partner and partner-to-AHI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by AHI1-low versus AHI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHI1→partner) and Y-score (partner→AHI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.409	+1.700	<.001	.040	3	3
UCEC	MSH2 →	-0.247	-1.880	.001	.014	3	2
UCEC	ATM →	-0.361	-1.874	.017	.002	3	2
UCEC	eIF4E →	+0.179	+1.874	.011	.002	3	1
UCEC	ERK2 →	+0.138	+2.321	.032	.005	3	1
UCEC	IGFBP2 →	-0.556	-1.584	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by AHI1 expression — UCEC

Explore this box plot interactively →