AHI1

Across TCGA cell cohorts, AHI1 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AHI1-associated genes across cancer lineages are CMA1, PHOX2B, and CCKBR. Each is linked with AHI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AHI1-to-partner and partner-to-AHI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMA1 grouped by AHI1-low versus AHI1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHI1→partner) and Y-score (partner→AHI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CMA1 →	+0.033	+3.082	<.001	.005	3	2
BLOOD_Leukemia	PHOX2B →	+0.013	+3.365	.006	.005	3	2
BLOOD_Leukemia	CCKBR →	+0.511	+4.127	.003	<.001	3	2
BLOOD_Leukemia	DSG1 →	+0.105	+3.594	.002	.007	3	2
BLOOD_Leukemia	GJD4 →	+0.036	+4.430	<.001	<.001	3	2
BLOOD_Leukemia	NPSR1 →	+0.023	+2.982	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

CMA1 by AHI1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →