AHDC1

Across TCGA pan-cancer cohorts, AHDC1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AHDC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AHDC1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AHDC1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where AHDC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AHDC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.442	<.001	12	view →
LSCC	Female	All	+0.419	<.001	8	view →
CCRCC	Male	All	+0.235	<.001	6	view →
COAD	All	All	−0.590	.031	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

AHDC1–HNSC

Open the HNSC breakdown →