AHDC1

Across TCGA patient cohorts, AHDC1 mutation is significantly associated with the RNA expression of many other genes, with 4,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHDC1-associated genes across cancer lineages are ATP5IF1, PBK, and CDKN3. Each is linked with AHDC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AHDC1-to-partner and partner-to-AHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5IF1 grouped by AHDC1-low versus AHDC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHDC1→partner) and Y-score (partner→AHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP5IF1 →	+0.352	+2.279	.002	.005	3	5
UCEC	PBK →	+0.983	+2.711	<.001	<.001	3	4
UCEC	CDKN3 →	+0.786	+3.818	<.001	<.001	3	4
UCEC	RAD51C →	+0.455	+2.010	<.001	<.001	3	4
UCEC	SDHB →	+0.515	+3.807	<.001	<.001	3	4
UCEC	AUNIP →	+0.556	+2.321	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,443 associations by consensus.

ATP5IF1 by AHDC1 expression — SKCM

Explore this box plot interactively →