AHDC1

Across TCGA patient cohorts, AHDC1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHDC1-associated genes across cancer lineages are NF2, ASNS, and eEF2. Each is linked with AHDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AHDC1-to-partner and partner-to-AHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by AHDC1-low versus AHDC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHDC1→partner) and Y-score (partner→AHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NF2 →	+0.256	+2.815	.016	.036	3	2
SKCM	ASNS →	+0.536	+2.115	.004	.018	3	2
UCEC	eEF2 →	+0.376	+2.070	.002	.001	3	2
UCEC	EGFR_pY1068 →	-0.246	-1.736	.004	.007	3	2
UCEC	eIF4E →	+0.205	+3.087	.005	<.001	3	2
UCEC	A-Raf_pS299 →	-0.144	-1.807	<.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

NF2 by AHDC1 expression — COAD

Explore this box plot interactively →