AHDC1

Across TCGA cell cohorts, AHDC1 mutation is significantly associated with the mutation status of many other genes, with 5,906 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHDC1-associated genes across cancer lineages are RYR2, SPEN, and GRM8. Each is linked with AHDC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both AHDC1-to-partner and partner-to-AHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RYR2 grouped by AHDC1-low versus AHDC1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHDC1→partner) and Y-score (partner→AHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RYR2 →	+2.325	+3.479	<.001	<.001	1	6
SOFT_TISSUE	SPEN →	+5.022	+4.066	.001	.001	1	6
BLOOD_Leukemia	GRM8 →	+3.156	+2.465	.005	.005	1	6
OVARY	MYO9B →	+4.009	+3.421	<.001	<.001	1	6
BLOOD_Leukemia	SYNE1 →	+1.625	+2.746	<.001	<.001	1	6
PANCREAS	LAMA4 →	+4.139	+2.935	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,906 associations by consensus.

RYR2 by AHDC1 expression — OVARY

Explore this box plot interactively →