AHCYL2

Across TCGA patient cohorts, AHCYL2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCYL2-associated genes across cancer lineages are eEF2, A-Raf_pS299, and GAPDH. Each is linked with AHCYL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AHCYL2-to-partner and partner-to-AHCYL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AHCYL2-low versus AHCYL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCYL2→partner) and Y-score (partner→AHCYL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.357	+2.321	.013	.034	3	2
UCEC	A-Raf_pS299 →	-0.131	-2.321	.006	.033	3	2
UCEC	GAPDH →	+0.625	+3.584	.003	.002	3	2
UCEC	MEK1 →	+0.524	+3.807	<.001	<.001	3	2
UCEC	PDCD4 →	-0.654	-2.000	<.001	.029	3	2
UCEC	Shc_pY317 →	-0.190	-3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by AHCYL2 expression — UCEC

Explore this box plot interactively →