AHCY

Across TCGA patient cohorts, AHCY protein abundance is significantly associated with the RNA expression of many other genes, with 14,099 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AHCY-associated genes across cancer lineages are PIGU, PDE1B, and ITCH. Each is linked with AHCY in more than 8 cancer types. Because this analysis shows association rather than direction, both AHCY-to-partner and partner-to-AHCY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AHCY versus PIGU in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCY→partner) and Y-score (partner→AHCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIGU →	+0.637	+0.295	.001	<.001	3	9
OV	PDE1B →	-0.713	-0.328	<.001	<.001	3	7
HNSC	ITCH →	+0.484	+0.262	<.001	<.001	3	7
OV	SYNPO →	-0.942	-0.280	.004	.008	3	6
LSCC	FASTKD5 →	+0.497	+0.267	<.001	<.001	3	6
HNSC	GID8 →	+0.710	+0.213	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,099 associations by consensus.

AHCY vs PIGU — HNSC

Explore this scatter interactively →