AHCY

Across TCGA patient cohorts, AHCY mutation is significantly associated with the RNA expression of many other genes, with 1,259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCY-associated genes across cancer lineages are KMT5A, CDCA2, and TARS3. Each is linked with AHCY in more than 1 cancer types. Because this analysis shows association rather than direction, both AHCY-to-partner and partner-to-AHCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT5A grouped by AHCY-low versus AHCY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCY→partner) and Y-score (partner→AHCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KMT5A →	+0.361	+2.606	.005	.005	3	2
UCEC	CDCA2 →	+0.732	+3.321	.001	<.001	3	2
UCEC	TARS3 →	+0.420	+3.524	.003	.002	3	2
UCEC	FAM120AOS →	+0.500	+1.776	<.001	.008	3	2
UCEC	ZNF79 →	+0.347	+2.600	.003	.006	3	2
UCEC	SBDSP1 →	+0.543	+1.776	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,259 associations by consensus.

KMT5A by AHCY expression — UCEC

Explore this box plot interactively →