AHCY

Across TCGA patient cohorts, AHCY mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCY-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Notch1. Each is linked with AHCY in more than 1 cancer types. Because this analysis shows association rather than direction, both AHCY-to-partner and partner-to-AHCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AHCY-low versus AHCY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCY→partner) and Y-score (partner→AHCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.213	+3.459	.017	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.157	-2.321	.028	.034	3	1
UCEC	Notch1 →	+0.130	+1.700	.029	.044	3	1
UCEC	p62 Lck ligand →	+0.504	+4.000	<.001	<.001	3	1
UCEC	p90 RSK →	+0.190	+2.235	.019	.006	3	1
UCEC	S6_pS240_S244 →	+0.343	+3.169	.047	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by AHCY expression — UCEC

Explore this box plot interactively →