AHCY

Across TCGA cell cohorts, AHCY RNA expression is significantly associated with the go_rna of many other GO terms, with 5,196 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AHCY-associated GO terms across cancer lineages are Amino acid activation, tRNA aminoacylation, and 'de novo' IMP biosynthetic process. Each is linked with AHCY in more than 13 cancer types. Because this analysis shows association rather than direction, both AHCY-to-partner and partner-to-AHCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino acid activation grouped by AHCY-low versus AHCY-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCY→partner) and Y-score (partner→AHCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Amino acid activation →	+0.104	+1.091	<.001	<.001	3	14
BONE	tRNA aminoacylation →	+0.104	+1.091	<.001	<.001	3	14
URINARY_TRACT	'de novo' IMP biosynthetic process →	+0.141	+0.875	<.001	.001	3	14
BONE	rRNA processing →	+0.109	+0.807	.001	.001	3	14
URINARY_TRACT	IMP metabolic process →	+0.168	+0.895	<.001	<.001	3	13
LUNG_SCLC	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.113	+0.646	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,196 associations by consensus.

Amino acid activation by AHCY expression — BONE

Explore this box plot interactively →