AHCY

Across TCGA cell cohorts, AHCY mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHCY-associated genes across cancer lineages are C6orf118, ACSM6, and PRAMEF20. Each is linked with AHCY in more than 1 cancer types. Because this analysis shows association rather than direction, both AHCY-to-partner and partner-to-AHCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by AHCY-low versus AHCY-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCY→partner) and Y-score (partner→AHCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	CWH43 →	+0.037	+3.544	<.001	.001	3	1
BLOOD_Lymphoma	ARMH2 →	+0.093	+2.984	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C6orf118 by AHCY expression — LARGE_INTESTINE

Explore this box plot interactively →