AHCTF1

Across TCGA patient cohorts, AHCTF1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCTF1-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and ACC_pS79. Each is linked with AHCTF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AHCTF1-to-partner and partner-to-AHCTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by AHCTF1-low versus AHCTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCTF1→partner) and Y-score (partner→AHCTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.135	-1.379	.027	.015	3	4
STAD	Caspase-7-cleavedD198 →	+0.732	+3.169	.045	.019	2	4
LUSC	ACC_pS79 →	+0.462	+3.009	.010	.019	3	3
UCEC	Ku80 →	+0.255	+1.688	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.232	-1.000	.041	.048	3	3
UCEC	STAT3_pY705 →	-0.314	-1.440	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Rad50 by AHCTF1 expression — UCEC

Explore this box plot interactively →