AHCTF1

Across TCGA cell cohorts, AHCTF1 mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHCTF1-associated genes across cancer lineages are CES3, PDP2, and TMPRSS7. Each is linked with AHCTF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AHCTF1-to-partner and partner-to-AHCTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CES3 grouped by AHCTF1-low versus AHCTF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCTF1→partner) and Y-score (partner→AHCTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CES3 →	+1.547	+2.949	<.001	<.001	3	3
BLOOD_Leukemia	PDP2 →	+0.789	+3.299	.001	.004	3	2
BLOOD_Leukemia	TMPRSS7 →	+0.027	+2.206	<.001	.009	3	2
OVARY	UTY →	+0.028	+3.077	.003	.001	3	2
LARGE_INTESTINE	ZBED4 →	+0.537	+2.265	<.001	.001	3	2
LARGE_INTESTINE	TTC19 →	+0.690	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

CES3 by AHCTF1 expression — LARGE_INTESTINE

Explore this box plot interactively →