AGXT2

Across TCGA cell cohorts, AGXT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 211 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AGXT2-associated GO terms across cancer lineages are L-homocysteine catabolic process, Vesicle-mediated cholesterol transport, and Negative regulation of kidney development. Each is linked with AGXT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGXT2-to-partner and partner-to-AGXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-homocysteine catabolic process grouped by AGXT2-low versus AGXT2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGXT2→partner) and Y-score (partner→AGXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	L-homocysteine catabolic process →	+0.190	+0.009	.001	.008	2	3
OVARY	Vesicle-mediated cholesterol transport →	+0.137	+0.010	<.001	.009	3	2
OVARY	Negative regulation of kidney development →	-0.218	-0.010	.005	.009	3	2
OVARY	Intestinal lipid absorption →	+0.272	+0.010	<.001	.009	3	2
LUNG_SCLC	Postsynaptic neurotransmitter receptor internalization →	+0.169	+0.017	<.001	.003	3	2
LUNG_SCLC	Neurotransmitter receptor internalization →	+0.169	+0.017	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

L-homocysteine catabolic process by AGXT2 expression — LARGE_INTESTINE

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