AGXT2

Across TCGA cell cohorts, AGXT2 mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGXT2-associated genes across cancer lineages are TEX13A, ERVV-2, and AWAT2. Each is linked with AGXT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGXT2-to-partner and partner-to-AGXT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX13A grouped by AGXT2-low versus AGXT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGXT2→partner) and Y-score (partner→AGXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX13A →	+0.032	+4.554	<.001	<.001	3	2
BLOOD_Leukemia	ERVV-2 →	+0.174	+3.106	<.001	.005	3	2
LUNG_NSCLC_LUSC	AWAT2 →	+0.016	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	PRSS54 →	+0.077	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR6C6 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR2A2 →	+0.162	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

TEX13A by AGXT2 expression — BLOOD_Leukemia

Explore this box plot interactively →