AGXT

Across TCGA cell cohorts, AGXT RNA expression is significantly associated with the go_rna of many other GO terms, with 476 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGXT-associated GO terms across cancer lineages are Negative regulation of CD4-positive, alpha-beta T cell differentiation, Branched-chain amino acid metabolic process, and Branched-chain amino acid catabolic process. Each is linked with AGXT in more than 3 cancer types. Because this analysis shows association rather than direction, both AGXT-to-partner and partner-to-AGXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of CD4-positive, alpha-beta T cell differentiation grouped by AGXT-low versus AGXT-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGXT→partner) and Y-score (partner→AGXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of CD4-positive, alpha-beta T cell differentiation →	-0.154	-1.797	.001	.009	3	4
LARGE_INTESTINE	Branched-chain amino acid metabolic process →	+0.074	+0.212	<.001	.008	3	4
LARGE_INTESTINE	Branched-chain amino acid catabolic process →	+0.066	+0.229	<.001	.004	3	4
BREAST	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.159	-0.616	<.001	.008	2	4
BREAST	Regulation of plasma lipoprotein particle levels →	-0.071	-0.606	<.001	.009	3	3
BREAST	Regulation of CD4-positive, alpha-beta T cell proliferation →	-0.161	-0.906	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

Negative regulation of CD4-positive, alpha-beta T cell differentiation by AGXT expression — LIVER

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