AGXT

Across TCGA cell cohorts, AGXT mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AGXT-associated genes across cancer lineages are MAGEB4, OR10W1, and DMRTB1. Each is linked with AGXT in more than 1 cancer types. Because this analysis shows association rather than direction, both AGXT-to-partner and partner-to-AGXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by AGXT-low versus AGXT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGXT→partner) and Y-score (partner→AGXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L3 →	+0.028	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.036	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by AGXT expression — LARGE_INTESTINE

Explore this box plot interactively →