AGTR2

Across TCGA pan-cancer cohorts, AGTR2 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated AGTR2 data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher AGTR2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AGTR2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

MESO, UCEC, and KIRC are the cancer types where AGTR2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.069	0.580	<.001	36	view →
UCEC	DFS	Median	II,III,IV	1.000	0.298	.001	34	view →
KIRC	OS	Median	All	0.172	0.805	.001	24	view →
LIHC	DFS	Median	All	0.055	0.556	<.001	22	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
COAD	OS	Median	III,IV	0.221	0.782	.013	9	view →
LUAD	DFS	Median	All	0.371	0.680	.020	8	view →
SKCM	DFS	Median	III,IV	0.623	0.236	.020	8	view →
LGG	DFS	Median	All	0.268	0.753	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

AGTR2–MESO (OS)

Open the MESO breakdown →