AGT

Across TCGA patient cohorts, AGT mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGT-associated genes across cancer lineages are ERK2, Annexin-1, and XBP1. Each is linked with AGT in more than 2 cancer types. Because this analysis shows association rather than direction, both AGT-to-partner and partner-to-AGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by AGT-low versus AGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGT→partner) and Y-score (partner→AGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.227	+3.584	.001	.002	3	3
UCEC	Annexin-1 →	+0.690	+3.827	<.001	<.001	3	2
UCEC	XBP1 →	-0.135	-2.000	.009	.030	3	2
UCEC	ASNS →	+0.312	+1.700	.018	.042	3	2
UCEC	EGFR_pY1068 →	-0.268	-2.247	.003	.001	3	1
UCEC	EGFR →	-0.179	-2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ERK2 by AGT expression — UCEC

Explore this box plot interactively →