AGT

Across TCGA cell cohorts, AGT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,802 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AGT-associated GO terms across cancer lineages are Maintenance of blood vessel diameter homeostasis by renin-angiotensin, Regulation of membrane hyperpolarization, and Regulation of renal sodium excretion. Each is linked with AGT in more than 12 cancer types. Because this analysis shows association rather than direction, both AGT-to-partner and partner-to-AGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of blood vessel diameter homeostasis by renin-angiotensin grouped by AGT-low versus AGT-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGT→partner) and Y-score (partner→AGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Maintenance of blood vessel diameter homeostasis by renin-angiotensin →	+1.856	+5.561	<.001	<.001	3	13
KIDNEY	Regulation of membrane hyperpolarization →	-0.275	-1.783	<.001	.001	3	11
LUNG_SCLC	Regulation of renal sodium excretion →	+1.566	+4.208	<.001	<.001	3	10
BONE	Renal system process involved in regulation of systemic arterial blood pressure →	+1.224	+1.354	<.001	<.001	3	9
BONE	Cellular response to unfolded protein →	+0.083	+1.607	.002	.004	3	8
LUNG_SCLC	Positive regulation of lipid biosynthetic process →	+0.064	+2.714	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,802 associations by consensus.

Maintenance of blood vessel diameter homeostasis by renin-angiotensin by AGT expression — LIVER

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