AGT

Across TCGA cell cohorts, AGT mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGT-associated genes across cancer lineages are RTP1, CCR8, and CRISP1. Each is linked with AGT in more than 1 cancer types. Because this analysis shows association rather than direction, both AGT-to-partner and partner-to-AGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP1 grouped by AGT-low versus AGT-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGT→partner) and Y-score (partner→AGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RTP1 →	+0.025	+4.459	<.001	.001	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LIVER	CRISP1 →	+0.028	+3.977	<.001	.006	3	1
LIVER	FAM240A →	+0.007	+3.977	<.001	.006	3	1
LUNG_SCLC	KRTAP6-1 →	+0.070	+5.643	<.001	.002	3	1
LUNG_SCLC	SCGB1C2 →	+0.341	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

RTP1 by AGT expression — LIVER

Explore this box plot interactively →