AGRP

Across TCGA patient cohorts, AGRP mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGRP-associated genes across cancer lineages are SEPTIN14P19, RNU6-467P, and OR4X2. Each is linked with AGRP in more than 1 cancer types. Because this analysis shows association rather than direction, both AGRP-to-partner and partner-to-AGRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by AGRP-low versus AGRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGRP→partner) and Y-score (partner→AGRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN14P19 →	+0.052	+4.923	<.001	.002	3	1
UCEC	RNU6-467P →	+0.308	+4.400	<.001	.006	3	1
COAD	OR4X2 →	+0.054	+7.741	<.001	.009	3	1
COAD	OR51V1 →	+0.103	+7.741	<.001	.009	3	1
UCEC	OR6K3 →	+0.127	+3.567	.001	.005	3	1
UCEC	NUP35P2 →	+0.063	+3.827	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SEPTIN14P19 by AGRP expression — UCEC

Explore this box plot interactively →