Across TCGA pan-cancer cohorts, AGRN mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AGRN data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AGRN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGRN expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where AGRN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.341	0.746	.002	76	view →
CCRCC	DFS	Median	III,IV	0.849	0.494	.004	20	view →
LSCC	OS	Median	All	0.698	0.865	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: AGRN tumor-vs-normal RNA expression · all AGRN data types