Across TCGA patient cohorts, AGRN protein abundance is significantly associated with the RNA expression of many other genes, with 12,224 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible AGRN-associated genes across cancer lineages are ADAMTS9-AS2, TIMP3, and MYCT1. Each is linked with AGRN in more than 6 cancer types. Because this analysis shows association rather than direction, both AGRN-to-partner and partner-to-AGRN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGRN→partner) and Y-score (partner→AGRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADAMTS9-AS2 →	+0.782	+0.477	<.001	<.001	3	7
HNSC	TIMP3 →	+1.484	+0.593	<.001	<.001	3	6
CCRCC	MYCT1 →	+1.101	+0.548	<.001	<.001	3	6
UCEC	PTH1R →	+0.655	+0.293	.002	.003	3	6
CCRCC	BCL6B →	+0.897	+0.431	<.001	<.001	3	6
CCRCC	FZD4 →	+0.956	+0.506	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,224 associations by consensus.

Exploration

AGRN survival (RNA) · tumor vs normal (RNA) · all AGRN data types