Across TCGA patient cohorts, AGRN mutation is significantly associated with the RNA expression of many other genes, with 3,069 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGRN-associated genes across cancer lineages are HASPIN, SRSF4, and ZWINT. Each is linked with AGRN in more than 3 cancer types. Because this analysis shows association rather than direction, both AGRN-to-partner and partner-to-AGRN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGRN→partner) and Y-score (partner→AGRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HASPIN →	+0.677	+1.700	<.001	.002	3	4
UCEC	SRSF4 →	+0.319	+1.947	.001	<.001	3	4
UCEC	ZWINT →	+0.567	+1.955	.001	.001	3	4
COAD	RPL17P50 →	+0.752	+2.441	<.001	.001	3	4
CESC	MZT1 →	+0.815	+3.239	<.001	.008	3	3
LGG	ERHP2 →	+0.145	+6.787	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,069 associations by consensus.

Exploration

AGRN survival (RNA) · tumor vs normal (RNA) · all AGRN data types