Across TCGA cell cohorts, AGRN mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGRN-associated genes across cancer lineages are PPIL4, ACTR6, and OR5C1. Each is linked with AGRN in more than 2 cancer types. Because this analysis shows association rather than direction, both AGRN-to-partner and partner-to-AGRN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGRN→partner) and Y-score (partner→AGRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPIL4 →	+0.448	+2.265	.005	.001	3	3
LARGE_INTESTINE	ACTR6 →	+0.514	+2.459	.002	.006	3	3
LIVER	OR5C1 →	+0.032	+3.459	.001	.004	3	2
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	2
PANCREAS	LCE2A →	+0.033	+5.614	<.001	.002	3	2
BLOOD_Leukemia	MAST1 →	+1.065	+3.459	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

Exploration

AGRN survival (RNA) · tumor vs normal (RNA) · all AGRN data types